PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells
نویسندگان
چکیده
منابع مشابه
MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells.
Human gastric cancers contain a population of gastric cancer stem cells (GCSCs) that can undergo self-renewal and multipotent differentiation. GCSCs can be enriched with EpCAM+/CD44+ gastric cancer cells. However, the underlying mechanisms controlling the balance of GCSC self-renewal and differentiation remain to be explored. Because miRNAs can regulate cancer cell fates, we compared miRNA expr...
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Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors. We discovered an endoglin (CD105)-expressing subpopulation in human RCC xenografts and patient samples with a greater capability to form spheres in vitro and tumors in mice at low dilutions than parental cells. Knockd...
متن کاملThe Wnt/β-catenin pathway regulates self-renewal of cancer stem-like cells in human gastric cancer.
Cancer stem cells (CSCs) possess the ability of self-renewal and tumor initiation. Targeting key signaling pathways that are active in CSC self-renewal is one approach to cancer therapy. Abnormal activation of the Wnt/β-catenin pathway has been described in a wide variety of human cancers and in CSCs; however, the role of this pathway in gastric CSCs has not been reported. In our study, we inve...
متن کاملMiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells Running title: miR-19b/20a/92a regulate self-renewal
1 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi, 710032,China 2 Ningxia Medical University Affiliated Hospital, Yinchuan, Ningxia, 750004, China. 3 These authors contributed equally to this work. Correspondence State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military M...
متن کاملCancer stem cells and self-renewal.
The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs a...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2017
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-16-0750